Hướng dẫn cắt đốt qua Catheter các rối loạn nhịp ở trẻ em - Bùi Thế Dũng
3 main issues
1. Safety - Efficacy
2. Procedure:
• laboratory equipment
• personnel
• ablation energy
• catheter choice
• sedation/anesthesia
• pre- and post-ablation procedure management
3. Arrhythmia typeSAFETY - EFFICACY
The 2002 consensus: depended on patient age,
typically expressed as “< or > 5 years”
HRS 2014: 2 groups: ≤ 12 years or 12 – 18
years
The 2016 consensus: patient weight was more
important than age – chose cutoff “15 kg”
Succes rate of RFCA:
1991 – 1995 (Early Era, n=4193): 90.4%
1996 – 1999 (Late Era, n=3407): 95.2%
.69 – 0.53% thrombi or emboli: 0.37 – 0.19% Fluoroscopy Exposure Deterministic effects (threshold level is 2 Gy) Stochastic effects (dose independent) Skin erythema Malignancies: 0.02% – 0.03% Epilation Hereditary defects Cataracts Retarded bone growth Sterility Decreased white blood cell Organ atrophy Fibrosis Techniques to Reduce Procedure-Based Radiation 1. As Low as Reasonably Achievable (ALARA) • Pulsed fluoroscopy • Lower frame rate • Adjusting collimators to decrease field view • Limiting the use of magnification • “store fluoro” function instead of cineangiography • Alternating between two views rather than a single imaging view to minimize site exposure 2. Nonfluoroscopic systems • 3-D imaging systems + TEE or ICE Anesthesia and Sedation Aims: improve patient comfort, reduce movement, and have minimal effect on the arrhythmia substrate Personnel: • Pts > 12 years: nurse anesthetist • Pts ≤ 12 years: nurse anesthetist + anesthesiologist General anesthesia with endotracheal intubation or laryngeal mask: age ≤ 12 years, significant CHD; ventricular dysfunction; pulmonary hypertension; hemodynamic instability; prolonged procedure; the need for complete immobility and patient or parent choice. Safety Recommendations Class I In-house pediatric cardiovascular surgical support for patients < 15 kg A pediatric (or congenital) cardiovascular surgical program at the same institution where the ablation is performed for patients ≤ 12 years of ages Age-appropriate cardiovascular surgical program and back-up at the same institution where the ablation is performed for patients from 12 to 18 years of ages Safety Recommendations Class I For patients ≤ 12 years of and/or with moderate or complex CHD, the procedure staff should have a pediatric and/or CHD pts anesthesiologist Fluoroscopy use should be as low as possible Anticoagulation with unfractionated heparin: When the procedure will take place in the left atrium or ventricle, or there is a known or potential right-to-left shunt to prevent systemic embolization (ACT: 250 – 300 s during procedures) Safety Recommendations Class IIa Cryoablation is useful for septal substrates and proximity to smaller coronary arteries Class IIb Cryoablation can be useful for pts < 15 kg Class III Ablation is not recommended for patients with an intracardiac thrombus Procedural Recommendations Class I EP lab and postprocedure recovery unit should be suitable for the care of pediatric and CHD pts Ablation for patients with moderate or complex CHD or complex arrhythmias should be performed by an electrophysiologist with the appropriate expertise 3D mapping system should be available and strongly considered for mapping and ablation of postoperative arrhythmias in patients with moderate or complex CHD Procedural Recommendations Class IIa Irrigated or large electrode-tip RF catheters can be useful for the ablation of postoperative arrhythmias in patients with CHD Nonfluoroscopic imaging can be useful to reduce radiation exposure Cryoablation can be useful for slow pathway modification in pediatric patients with AVNRT Clinical Presentations 1. SVT • AVNRT • AVRT • AT • AFL 2. WPW pattern and AP mediated Tachycardias 3. VT Indications for SVT Ablation Class I Documented SVT, recurrent or persistent associated with ventricular dysfunction in pts > 15 kg Documented SVT, recurrent or persistent when medical therapy is either not effective or is intolerant Documented SVT, recurrent or persistent when the family wishes to avoid chronic drugs in pts > 15 kg Recurrent hemodynamic compromise (hypotension or syncope) from SVT in pts > 15 kg Recurrent SVT requiring emergency medical care or electrical cardioversion for termination in pts > 15 kg Indications for SVT Ablation Class II a Recurrent symptoms clearly consistent with PSVT in pts > 15 kg, and one of the following: evidence of AP involvement; inducible SVT Slow pathway modification in pts > 15 kg with documented SVT, when SVT is not inducible at EP testing, but evidence for dual AV nodal physiology. Cryotherapy should be considered Indications for SVT Ablation Class II b Recurrent symptoms clearly consistent with PSVT in pts < 15 kg, and one of the following: evidence of AP; inducible SVT. Cryotherapy should be considered Recurrent hypotension or syncope from SVT in pts < 15 kg Intermittent symptomatic SVT which is nonsustained (less than 30s) in pts > 15kg Indications for SVT Ablation Class III SVT controlled with medical therapy without intolerable adverse effects in pts < 15 kg Clinical symptoms consistent with SVT, but no inducible SVT, and no evidence for dual AV nodal physiology during EP testing Slow pathway modification when dual AV node physiology is demonstrated after ablation of a different arrhythmia substrate (such as an AP when there is no inducible AVNRT Indications for WPW pattern Ablation Class I WPW pattern following cardiac arrest WPW pattern with syncope when there are predictors of high risk for cardiac arrest (The shortest preexcited RR interval during AF, or during incremental atrial pacing ≤ 250 ms; Multiple accessory pathways) Indications for WPW pattern Ablation Class II a WPW pattern with ventricular dysfunction in pts > 15 kg, or when medical therapy is either not effective or intolerant in pts < 15 kg WPW pattern with predictors of high risk for cardiac arrest in pts > 15 kg WPW pattern with syncope, without predictors of high risk for cardiac arrest in pts > 15 kg Asymtomatic WPW pattern in pts > 15 kg when the absence of WPW pattern is a prerequisite for participation in personal or professional activities Indications for WPW pattern Ablation Class II b Asymtomatic WPW pattern in pts > 15 kg without high risk for cardiac arrest because of a patient or family choice Class III WPW pattern caused by a fasciculoventricular accessory pathway WPW pattern without symptoms in pts < 15 kg Indications for ablation of ventricular arrhythmias without CHD Class I VPCs or VT caused ventricular dysfunction, when medical therapy is either not effective or intolerant, or as an alternative to medical therapy in pts > 15 kg Recurrent or persistent symptomatic verapamil – sensitive VT, idiopathic outflow tract VT, or VT with hemodynamic compromise, when medical therapy is either not effective or intolerant, or as an alternative to medical therapy in pts > 15 kg (LOVT-VT was a Class IIa indication in the prior pediatric guidelines) Indications for ablation of ventricular arrhythmias without CHD Class II a VPCs with correlated symptoms in pts > 15 kg Class II b Accelerated idioventricular rhythm with correlated symptoms in pts > 15 kg (Class IIa in the prior pediatric guidelines) Recurrent/frequent polymorphic ventricular arrhythmia when there is a suspected triggering focus, arrhythmia, or substrate that can be targeted Indications for ablation of ventricular arrhythmias without CHD Class III VT in pts < 15 kg controlled medically, or is well tolerated without ventricular dysfunction Acc. idioventricular rhythm in pts < 15kg Asymptomatic VPCs, VT, or accelerated idioventricular rhythm that is not suspected of causing or leading to ventricular dysfunction VPCs, VT due to transient reversible causes Indications for ablations in patients with CHD Class I Recurrent or persistent AT, SVT related to AP or twin AV nodes in patients with CHD when medical therapy is either not effective or intolerant. Ablation is also recommended as an alternative to medical therapy for pts > 15 kg WPW pattern and high-risk, commonly in Ebstein’s anomaly, in pts > 15 kg Ablation as adjunctive therapy to an ICD in pts with recurrent monomorphic VT, a VT storm, or multiple appropriate shocks that are not manageable by device reprogramming or drug Indications for ablations in patients with CHD Class II a • Sustained monomorphic VT causing symptoms or hypotension, when drug therapy is not effective or intolerant. Ablation is an alternative to medical therapy in pts > 15 kg • AVNRT when medical therapy is either not effective or intolerant in pts > 15 kg with moderate or complex CHD Class I Indications for Ablation for Infants and Patients <15 kg Pediatric cardiovascular surgical support should be available in-house during ablation procedures Documented SVT, when medical therapy is either not effective or intolerant WPW pattern following resuscitated cardiac arrest WPW pattern with syncope when there are predictors of high risk for cardiac arrest Idiopathic JET, or congenital JET associated with ventricular dysfunction, when medical therapy is either not effective or intolerant (cryotherapy is preferred) Class I Indications for Ablation for Infants and Patients <15 kg VPC or VT with ventricular dysfunction, when medical therapy is not effective or intolerant SVT related to accessory AV connections or twin AV nodes in patients with CHD when medical therapy is either not effective or intolerant Symptomatic AT occurring outside the early postoperative phase (less than 3 – 6 months) in patients with CHD, when medical therapy is either not effective or intolerant Summary The important roles of advancements in imaging technologies and ablation energy sources • nonfluoroscopic systems • higher-energy RF sources • cryoenergy Patient weight was more important than age High succes rate and safety if follow guideline
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