Therapeutic strategies for Hypertrophic Cardiomyopathy patient with Syncope - Nguyễn Thị Mai Ngọc

 Therapeutic strategies for 
Hypertrophic Cardiomyopathy patient with 
Syncope. 
Nguyen Thi Mai Ngoc MD, PhD 
Viet Nam National Heart Institute 
Bach Mai General Hospital 
 Definition of syncope and sudden death 
 Syncope was defined as a sudden and 
brief loss of consciousness associated with a 
loss of postural tone and a spontaneous 
recovery. 
Prognosis profiles for HCM and targets for therapy 
Clinical pathways in HCM 
 Indication for ICDs in HCM 
 Definition of syncope and sudden death 
Family screening for HCM patients and family 
members 
 Genetic testing. 
 Interpretation. 
 Genetic Counseling. 
Characteristic & prognosis implication of myosin missense 
mutation in HCM: 
 High risk of sudden death: 
 Mutation Arg403Gln 
 Arg719Trp 
 Arg453Cys. 
 Intermediate risk of premature sudden death: 
 Arg249Gln 
 Glu930Lys 
 Carrier of other MYH7 mutations would normal risk of premature sudden 
death: Gly256Glu, Val606Meth, Leu908Val 
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